I use Toad for one-time queries. I don't do any kind of programming or stored procedures in Toad.
When I exit, I never want to save the changes in my editor. And since Toad usually crashes if I leave it alone for a while, I pretty much have to close it every time I'm done using it for a while. It gets a bit annoying having to tell it not to save my changes every time I need to close the program.
I would like to see a checkbox somewhere in the Options menu for "Prompt to save changes on exit".